2276680-91-0
2276680-91-0 structure
- Name: T-518
- Chemical Name: T-518
- CAS Number: 2276680-91-0
- Molecular Formula: C19H16F7N5O3
- Molecular Weight: 495.358
- Create Date: 2022-07-02 19:26:09
- Modify Date: 2024-07-24 10:07:21
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T-518 (T518) is a potent, highly selective, brain penetrant, oral HDAC6 inhibitor with IC50 of 36 nM.T-518 did not obviously inhibit human HDAC1, 4, or 7 at 10 uM, which belongs to Class I or Class IIa HDAC.T-518 showed brain penetration in an oral dose and blocked HDAC6-dependent tubulin deacetylation at Lys40 in mouse hippocampus.T-518 decreased RIPA-insoluble tau accumulation (3-month treatment, 1 and 3 mg/kg), restored impaired axonal transport and novel object recognition in the P301S tau Tg mouse (tauopathy model) by 2-week treatment with dose 1 and 3 mg/kg.
| Name | T-518 |
|---|
| Description | T-518 (T518) is a potent, highly selective, brain penetrant, oral HDAC6 inhibitor with IC50 of 36 nM.T-518 did not obviously inhibit human HDAC1, 4, or 7 at 10 uM, which belongs to Class I or Class IIa HDAC.T-518 showed brain penetration in an oral dose and blocked HDAC6-dependent tubulin deacetylation at Lys40 in mouse hippocampus.T-518 decreased RIPA-insoluble tau accumulation (3-month treatment, 1 and 3 mg/kg), restored impaired axonal transport and novel object recognition in the P301S tau Tg mouse (tauopathy model) by 2-week treatment with dose 1 and 3 mg/kg. |
|---|---|
| References | 1. Tomohiro Onishi, et al. Sci Rep. 2021 Jul 29;11(1):15423. |
| Molecular Formula | C19H16F7N5O3 |
|---|---|
| Molecular Weight | 495.358 |