T 3364366

Modify Date: 2025-08-27 14:17:24

T 3364366 Structure
T 3364366 structure
Common Name T 3364366
CAS Number 1356354-09-0 Molecular Weight 443.46
Density N/A Boiling Point N/A
Molecular Formula C18H16F3N3O3S2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of T 3364366


T-3364366 is a reversible, slow-binding, thienopyrimidinone delta-5 desaturase (D5D) inhibitor with IC50s of 1.9 nM and 2.1 nM in HepG2 and RLN-10 cells, respectively. T-3364366 exhibits potent D5D (IC500=19 nM) inhibitory activity and excellent selectivity away from delta-6 desaturase (D6D, IC50=6200 nM) and delta-9 desaturase (stearoyl-CoA desaturase, SCD,50 >10000 nM) in the enzymatic activity assay[1].

 Names

Name T-3364366

 T 3364366 Biological Activity

Description T-3364366 is a reversible, slow-binding, thienopyrimidinone delta-5 desaturase (D5D) inhibitor with IC50s of 1.9 nM and 2.1 nM in HepG2 and RLN-10 cells, respectively. T-3364366 exhibits potent D5D (IC500=19 nM) inhibitory activity and excellent selectivity away from delta-6 desaturase (D6D, IC50=6200 nM) and delta-9 desaturase (stearoyl-CoA desaturase, SCD,50 >10000 nM) in the enzymatic activity assay[1].
Related Catalog
References

[1]. Ikuo Miyahisa, et al. T-3364366 Targets the Desaturase Domain of Delta-5 Desaturase with Nanomolar Potency and a Multihour Residence Time. ACS Med Chem Lett. 2016 Aug 10;7(9):868-72.

 Chemical & Physical Properties

Molecular Formula C18H16F3N3O3S2
Molecular Weight 443.46
Storage condition -20°C
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