891020-54-5
891020-54-5 structure
- Name: T-521
- Chemical Name: 5-(Ethylsulfonyl)-2-(4-fluorophenyl)-4-(phenylsulfonyl)-1,3-oxazole
- CAS Number: 891020-54-5
- Molecular Formula: C26H27Cl2N5O2
- Molecular Weight: 395.425
- Create Date: 2020-01-12 06:48:50
- Modify Date: 2024-01-11 15:27:36
-
T-521 is a novel PLK1 PBD (Polo-box domain) inhibitor that specifically inhibits the PBD of PLK1 (IC50=1.22 uM), but not those of Plk2-3; impedes the interaction between Plk1 and Bub1, exhibits dramatic mitotic defects in HeLa cells; suppresses the growth of A549 cells in xenograft nude mice.
| Name | 5-(Ethylsulfonyl)-2-(4-fluorophenyl)-4-(phenylsulfonyl)-1,3-oxazole |
|---|---|
| Synonyms |
5-(Ethylsulfonyl)-2-(4-fluorophenyl)-4-(phenylsulfonyl)-1,3-oxazole
Oxazole, 5-(ethylsulfonyl)-2-(4-fluorophenyl)-4-(phenylsulfonyl)- |
| Description | T-521 is a novel PLK1 PBD (Polo-box domain) inhibitor that specifically inhibits the PBD of PLK1 (IC50=1.22 uM), but not those of Plk2-3; impedes the interaction between Plk1 and Bub1, exhibits dramatic mitotic defects in HeLa cells; suppresses the growth of A549 cells in xenograft nude mice. |
|---|---|
| References | References 1. Chen Y, et al. Oncotarget. 2017 Jan 3;8(1):1234-1246. View Related Products by Target Polo-like Kinase (PLK) |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 637.2±65.0 °C at 760 mmHg |
| Molecular Formula | C26H27Cl2N5O2 |
| Molecular Weight | 395.425 |
| Flash Point | 339.2±34.3 °C |
| Exact Mass | 395.029755 |
| LogP | 3.08 |
| Vapour Pressure | 0.0±1.8 mmHg at 25°C |
| Index of Refraction | 1.578 |