TH5427 hydrochloride
Modify Date: 2024-01-11 08:21:31
TH5427 hydrochloride structure
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Common Name | TH5427 hydrochloride | ||
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| CAS Number | 2253744-57-7 | Molecular Weight | 527.79 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C20H21Cl3N8O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of TH5427 hydrochlorideTH5427 hydrochloride is a potent, selective NUDT5 inhibitor (IC50=29 nM). TH5427 hydrochloride shows an apparent 690-fold selectivity for NUDT5 over MTH1. TH5427 hydrochloride blocks progestin-dependent, PAR-derived nuclear ATP synthesis and subsequent chromatin remodeling, gene regulation and proliferation in breast cancer cells[1]. |
| Name | TH5427 hydrochloride |
|---|
| Description | TH5427 hydrochloride is a potent, selective NUDT5 inhibitor (IC50=29 nM). TH5427 hydrochloride shows an apparent 690-fold selectivity for NUDT5 over MTH1. TH5427 hydrochloride blocks progestin-dependent, PAR-derived nuclear ATP synthesis and subsequent chromatin remodeling, gene regulation and proliferation in breast cancer cells[1]. |
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| Related Catalog | |
| In Vitro | TH5427 hydrochloride inhibits progestin-dependent nuclear ATP synthesis in breast cancer cells. TH5427 hydrochloride significantly disrupted EGFR and MMTV-luc expression following progestin stimulation. TH5427 hydrochloride abrogates the progestin-dependent proliferation response in T47DWT cells[1]. |
| References |
| Molecular Formula | C20H21Cl3N8O3 |
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| Molecular Weight | 527.79 |