2253744-56-6

2253744-56-6 structure

Name: TH5427
Chemical Name: TH5427
CAS Number: 2253744-56-6
Molecular Formula: C₂₀H₂₀Cl₂N₈O₃
Molecular Weight: 491.33
Catalog: Research Areas Cancer
Create Date: 2022-08-05 11:44:35
Modify Date: 2024-01-16 17:05:58
TH5427 is a promising, targeted inhibitor that can be used to further study NUDT5 activity and ADP-ribose metabolism. TH5427, blocks progestin-dependent, PAR-derived nuclear ATP synthesis and subsequent chromatin remodeling, gene regulation and proliferation in breast cancer cells. NUDT5 is recently identified as a rheostat of hormone-dependent gene regulation and proliferation in breast cancer cells[1].

Name	TH5427

Description	TH5427 is a promising, targeted inhibitor that can be used to further study NUDT5 activity and ADP-ribose metabolism. TH5427, blocks progestin-dependent, PAR-derived nuclear ATP synthesis and subsequent chromatin remodeling, gene regulation and proliferation in breast cancer cells. NUDT5 is recently identified as a rheostat of hormone-dependent gene regulation and proliferation in breast cancer cells[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
References	[1]. Page BDG, et al. Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells [published correction appears in Nat Commun. 2019 Nov 1;10(1):5050]. Nat Commun. 2018;9(1):250.

Molecular Formula	C₂₀H₂₀Cl₂N₈O₃
Molecular Weight	491.33