HIV-1 protease-IN-2
Modify Date: 2025-08-27 11:51:22
HIV-1 protease-IN-2 structure
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Common Name | HIV-1 protease-IN-2 | ||
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| CAS Number | 2248124-46-9 | Molecular Weight | 558.65 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C27H34N4O7S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of HIV-1 protease-IN-2HIV-1 protease-IN-2 is a potent HIV-1 protease inhibitor with an IC50 of 2.53 nM. HIV-1 protease-IN-2 shows antiviral activity against DRV (Darunavir)-sensitive or DRV-resistant HIV-1 variants[1]. |
| Name | HIV-1 protease-IN-2 |
|---|
| Description | HIV-1 protease-IN-2 is a potent HIV-1 protease inhibitor with an IC50 of 2.53 nM. HIV-1 protease-IN-2 shows antiviral activity against DRV (Darunavir)-sensitive or DRV-resistant HIV-1 variants[1]. |
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| Related Catalog | |
| Target |
IC50: 2.53 nM (HIV-1 protease)[1] |
| In Vitro | HIV-1 protease-IN-2 (compound 10e) (100 nM) shows a promising inhibition ratio of 68% at 100 nM for wild-type HIV-1[1]. HIV-1 protease-IN-2 (0-1000 nM) shows antiviral activity against DRV (Darunavir)-sensitive or resistant pseudotyped HIV-1 with EC50s of 0.27 µM and 0.59 µM for HIV-1NL4-3 and HIVRDRVS, respectively[1]. |
| References |
| Molecular Formula | C27H34N4O7S |
|---|---|
| Molecular Weight | 558.65 |
| InChIKey | YKVUCLKFVOEPGS-BJKOFHAPSA-N |
| SMILES | COc1ccc(S(=O)(=O)N(CC(C)C)CC(O)C(Cc2ccccc2)NC(=O)Cn2ccc(=O)[nH]c2=O)cc1 |