2248124-46-9

2248124-46-9 structure

Name: HIV-1 protease-IN-2
Chemical Name: HIV-1 protease-IN-2
CAS Number: 2248124-46-9
Molecular Formula: C₂₇H₃₄N₄O₇S
Molecular Weight: 558.65
Catalog: Signaling Pathways Metabolic Enzyme/Protease HIV Protease
Create Date: 2022-07-01 17:02:04
Modify Date: 2024-01-12 11:34:40
HIV-1 protease-IN-2 is a potent HIV-1 protease inhibitor with an IC50 of 2.53 nM. HIV-1 protease-IN-2 shows antiviral activity against DRV (Darunavir)-sensitive or DRV-resistant HIV-1 variants[1].

Name	HIV-1 protease-IN-2

Description	HIV-1 protease-IN-2 is a potent HIV-1 protease inhibitor with an IC50 of 2.53 nM. HIV-1 protease-IN-2 shows antiviral activity against DRV (Darunavir)-sensitive or DRV-resistant HIV-1 variants[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Metabolic Enzyme/Protease >> HIV Protease
Target	IC50: 2.53 nM (HIV-1 protease)[1]
In Vitro	HIV-1 protease-IN-2 (compound 10e) (100 nM) shows a promising inhibition ratio of 68% at 100 nM for wild-type HIV-1[1]. HIV-1 protease-IN-2 (0-1000 nM) shows antiviral activity against DRV (Darunavir)-sensitive or resistant pseudotyped HIV-1 with EC50s of 0.27 µM and 0.59 µM for HIV-1NL4-3 and HIVRDRVS, respectively[1].
References	[1]. Zhu M, et al. Preliminary SAR and biological evaluation of potent HIV-1 protease inhibitors with pyrimidine bases as novel P2 ligands to enhance activity against DRV-resistant HIV-1 variants. Eur J Med Chem. 2020 Jan 1;185:111866.

Molecular Formula	C₂₇H₃₄N₄O₇S
Molecular Weight	558.65