HC-5404

Modify Date: 2025-09-05 11:34:36

HC-5404 structure	Common Name	HC-5404
	CAS Number	2247396-91-2	Molecular Weight	454.47
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₄H₂₄F₂N₄O₃	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of HC-5404

HC-5404 is a potent and selective PERK inhibitor. HC-5404 has orally activity. HC-5404 significantly blocks metastasis via killing quiescent/slow-cycling ISRhigh[1][2].

Name	HC-5404

Description	HC-5404 is a potent and selective PERK inhibitor. HC-5404 has orally activity. HC-5404 significantly blocks metastasis via killing quiescent/slow-cycling ISRhigh[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> PERK
References	[1]. Michael E Stokes, et al. PERK Inhibition by HC-5404 Sensitizes Renal Cell Carcinoma Tumor Models to Antiangiogenic Tyrosine Kinase Inhibitors. Clin Cancer Res. 2023, 29, 3. [2]. Veronica Calvo, et al. A PERK-Specific Inhibitor Blocks Metastatic Progression by Limiting Integrated Stress Response-Dependent Survival of Quiescent Cancer Cells. Clin Cancer Res. 2023.

Description

HC-5404 is a potent and selective PERK inhibitor. HC-5404 has orally activity. HC-5404 significantly blocks metastasis via killing quiescent/slow-cycling ISRhigh[1][2].

Related Catalog

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> PERK

References

[1]. Michael E Stokes, et al. PERK Inhibition by HC-5404 Sensitizes Renal Cell Carcinoma Tumor Models to Antiangiogenic Tyrosine Kinase Inhibitors. Clin Cancer Res. 2023, 29, 3.

[2]. Veronica Calvo, et al. A PERK-Specific Inhibitor Blocks Metastatic Progression by Limiting Integrated Stress Response-Dependent Survival of Quiescent Cancer Cells. Clin Cancer Res. 2023.