Shanghai Nianxing Industrial Co., Ltd
China
Product Name: HC-5404
Price: Check
Purity: 98.0%
Stocking Period: 10 Day
Contact: Yang
Email: sales@echemcloud.com

DC Chemicals Limited
China
Product Name: HC-5404
Price: ￥Inquiry/100mg ￥Inquiry/250mg ￥Inquiry/1g
Purity: 98.0%
Stocking Period: 10 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

2247396-91-2

2247396-91-2 structure

2247396-91-2 structure

Name: HC-5404
Chemical Name: HC-5404
CAS Number: 2247396-91-2
Molecular Formula: C₂₄H₂₄F₂N₄O₃
Molecular Weight: 454.47
Catalog: Signaling Pathways Cell Cycle/DNA Damage PERK
Create Date: 2023-12-19 13:52:47
Modify Date: 2025-09-05 11:34:36
HC-5404 is a potent and selective PERK inhibitor. HC-5404 has orally activity. HC-5404 significantly blocks metastasis via killing quiescent/slow-cycling ISRhigh[1][2].

Name	HC-5404

Description	HC-5404 is a potent and selective PERK inhibitor. HC-5404 has orally activity. HC-5404 significantly blocks metastasis via killing quiescent/slow-cycling ISRhigh[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> PERK
References	[1]. Michael E Stokes, et al. PERK Inhibition by HC-5404 Sensitizes Renal Cell Carcinoma Tumor Models to Antiangiogenic Tyrosine Kinase Inhibitors. Clin Cancer Res. 2023, 29, 3. [2]. Veronica Calvo, et al. A PERK-Specific Inhibitor Blocks Metastatic Progression by Limiting Integrated Stress Response-Dependent Survival of Quiescent Cancer Cells. Clin Cancer Res. 2023.

Molecular Formula	C₂₄H₂₄F₂N₄O₃
Molecular Weight	454.47

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