2'-Fluoro-5'-O-DMT-2'-deoxyinosine-3'-CE-phosphoramidite

Modify Date: 2024-01-28 10:59:53

2'-Fluoro-5'-O-DMT-2'-deoxyinosine-3'-CE-phosphoramidite structure	Common Name	2'-Fluoro-5'-O-DMT-2'-deoxyinosine-3'-CE-phosphoramidite
	CAS Number	2245842-16-2	Molecular Weight	772.80
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₄₀H₄₆FN₆O₇P	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of 2'-Fluoro-5'-O-DMT-2'-deoxyinosine-3'-CE-phosphoramidite

2'-Fluoro-5'-O-DMT-2'-deoxyinosine-3'-CE-phosphoramidite is a hypoxanthine analog. Hypoxanthine is a kind of purine base mainly present in muscle tissue. And it is a metabolite produced by purine oxidase acting on xanthine. Hypoxanthine has typical anti-inflammatory effects and is a potential endogenous poly(ADP-ribose) polymerase (PARP) inhibitor. It is cytoprotective by inhibiting PAPR activity, inhibiting peroxynitrite-induced mitochondrial depolarization and secondary superoxide production. Hypoxanthine can also be used as an indicator of hypoxia[1][2].

Name	2'-Fluoro-5'-O-DMT-2'-deoxyinosine-3'-CE-phosphoramidite

Description	2'-Fluoro-5'-O-DMT-2'-deoxyinosine-3'-CE-phosphoramidite is a hypoxanthine analog. Hypoxanthine is a kind of purine base mainly present in muscle tissue. And it is a metabolite produced by purine oxidase acting on xanthine. Hypoxanthine has typical anti-inflammatory effects and is a potential endogenous poly(ADP-ribose) polymerase (PARP) inhibitor. It is cytoprotective by inhibiting PAPR activity, inhibiting peroxynitrite-induced mitochondrial depolarization and secondary superoxide production. Hypoxanthine can also be used as an indicator of hypoxia[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog
References	[1]. Virág L, Szabó C. Purines inhibit poly(ADP-ribose) polymerase activation and modulate oxidant-induced cell death. FASEB J. 2001 Jan;15(1):99-107. [2]. Saugstad OD. Hypoxanthine as an indicator of hypoxia: its role in health and disease through free radical production. Pediatr Res. 1988 Feb;23(2):143-50.

Description

Related Catalog

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

References

[1]. Virág L, Szabó C. Purines inhibit poly(ADP-ribose) polymerase activation and modulate oxidant-induced cell death. FASEB J. 2001 Jan;15(1):99-107.

[2]. Saugstad OD. Hypoxanthine as an indicator of hypoxia: its role in health and disease through free radical production. Pediatr Res. 1988 Feb;23(2):143-50.

Molecular Formula	C₄₀H₄₆FN₆O₇P
Molecular Weight	772.80

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2'-Fluoro-5'-O-DMT-2'-deoxyinosine-3'-CE-phosphoramidite

Use of 2'-Fluoro-5'-O-DMT-2'-deoxyinosine-3'-CE-phosphoramidite

Names

Biological Activity

Chemical & Physical Properties

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.