Type II topoisomerase inhibitor 1
Modify Date: 2025-10-15 18:00:02
Type II topoisomerase inhibitor 1 structure
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Common Name | Type II topoisomerase inhibitor 1 | ||
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| CAS Number | 2245691-60-3 | Molecular Weight | 337.33 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C18H15N3O4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Type II topoisomerase inhibitor 1Type II topoisomerase inhibitor 1 is a potent and selective E. coli DNA gyrase inhibitor (IC50: 1.7 nM), and forms hydrogen bonds with Asp73 residue. Type II topoisomerase inhibitor 1 inhibits topoisomerase IV activity (IC50: 0.98 μM). Type II topoisomerase inhibitor 1 can be used in the research of antibacterial area[1][2]. |
| Name | Type II topoisomerase inhibitor 1 |
|---|
| Description | Type II topoisomerase inhibitor 1 is a potent and selective E. coli DNA gyrase inhibitor (IC50: 1.7 nM), and forms hydrogen bonds with Asp73 residue. Type II topoisomerase inhibitor 1 inhibits topoisomerase IV activity (IC50: 0.98 μM). Type II topoisomerase inhibitor 1 can be used in the research of antibacterial area[1][2]. |
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| Related Catalog | |
| Target |
topoisomerase IV:0.98 μM (IC50) DNA gyrase:1.7 nM (IC50) |
| In Vitro | Type II topoisomerase inhibitor 1 (13 e, 18 h) shows antibacterial activities against E. coli and S. aureus (MIC: 64 and 16 μg/mL, respectively)[1]. .Type II topoisomerase inhibitor 1 (50 μM, 48 h) shows an 8.4% inhibition rate for HepG2 cells[1]. . Cell Viability Assay[1] Cell Line: HepG2 cells Concentration: 10, 50 μM Incubation Time: 10, 50 μM Result: Showed cytoxicity with inhibition rates of 8.4% at 50 μM, 1.5% at 10 μM. |
| References |
| Molecular Formula | C18H15N3O4 |
|---|---|
| Molecular Weight | 337.33 |