ASP2453

Modify Date: 2025-08-25 16:35:05

ASP2453 structure	Common Name	ASP2453
	CAS Number	2241719-73-1	Molecular Weight	747.85
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₄₀H₄₈F₃N₇O₄	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of ASP2453

ASP2453 is a potent, selective and covalent KRAS G12C inhibitor. ASP2453 inhibits the Son of Sevenless (SOS)-mediated interaction between KRAS G12C and Raf with an IC50 value of 40 nM.

Name	ASP2453

Description	ASP2453 is a potent, selective and covalent KRAS G12C inhibitor. ASP2453 inhibits the Son of Sevenless (SOS)-mediated interaction between KRAS G12C and Raf with an IC50 value of 40 nM.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Ras
Target	KRas G12C:40 nM (IC50)
References	[1]. Nakayama A, et al. Characterisation of a novel KRAS G12C inhibitor ASP2453 that shows potent anti-tumour activity in KRAS G12C-mutated preclinical models. Br J Cancer. 2021 Nov 18.

Molecular Formula	C₄₀H₄₈F₃N₇O₄
Molecular Weight	747.85

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: ASP2453
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

DC Chemicals Limited
China
Product Name: ASP2453
Price: $1500.0/10mg
Purity: 98.0%
Delivery: 1 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

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ASP2453

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Chemical & Physical Properties

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.