Shanghai Nianxing Industrial Co., Ltd
China
Product Name: ASP2453
Price: Check
Purity: 98.0%
Stocking Period: 10 Day
Contact: Yang
Email: sales@echemcloud.com

DC Chemicals Limited
China
Product Name: ASP2453
Price: $1500.0/10mg
Purity: 98.0%
Stocking Period: 1 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

2241719-73-1

2241719-73-1 structure

2241719-73-1 structure

Name: ASP2453
Chemical Name: ASP2453
CAS Number: 2241719-73-1
Molecular Formula: C₄₀H₄₈F₃N₇O₄
Molecular Weight: 747.85
Catalog: Signaling Pathways GPCR/G Protein Ras
Create Date: 2022-01-17 16:50:23
Modify Date: 2024-01-05 17:58:30
ASP2453 is a potent, selective and covalent KRAS G12C inhibitor. ASP2453 inhibits the Son of Sevenless (SOS)-mediated interaction between KRAS G12C and Raf with an IC50 value of 40 nM.

Name	ASP2453

Description	ASP2453 is a potent, selective and covalent KRAS G12C inhibitor. ASP2453 inhibits the Son of Sevenless (SOS)-mediated interaction between KRAS G12C and Raf with an IC50 value of 40 nM.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Ras
Target	KRas G12C:40 nM (IC50)
References	[1]. Nakayama A, et al. Characterisation of a novel KRAS G12C inhibitor ASP2453 that shows potent anti-tumour activity in KRAS G12C-mutated preclinical models. Br J Cancer. 2021 Nov 18.

Molecular Formula	C₄₀H₄₈F₃N₇O₄
Molecular Weight	747.85

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