ASP2453

Names

[ Name ]:
ASP2453

Biological Activity

[Description]:

ASP2453 is a potent, selective and covalent KRAS G12C inhibitor. ASP2453 inhibits the Son of Sevenless (SOS)-mediated interaction between KRAS G12C and Raf with an IC50 value of 40 nM.

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Ras

[Target]

KRas G12C:40 nM (IC50)

[References]

[1]. Nakayama A, et al. Characterisation of a novel KRAS G12C inhibitor ASP2453 that shows potent anti-tumour activity in KRAS G12C-mutated preclinical models. Br J Cancer. 2021 Nov 18.

Chemical & Physical Properties

[ Molecular Formula ]:
C₄₀H₄₈F₃N₇O₄

[ Molecular Weight ]:
747.85

Related Compounds

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