HMR 1556

Modify Date: 2025-08-26 19:16:01

HMR 1556 structure	Common Name	HMR 1556
	CAS Number	223749-46-0	Molecular Weight	411.44
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₇H₂₄F₃NO₅S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of HMR 1556

HMR 1556, a chromanol derivative, is a IKs blocker with IC50s of 10.5 nM and 34 nM in canine and guinea pig left ventricular myocytes, respectively[1][2].

Name	HMR 1556

Description	HMR 1556, a chromanol derivative, is a IKs blocker with IC50s of 10.5 nM and 34 nM in canine and guinea pig left ventricular myocytes, respectively[1][2].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel
Target	IC50: 10.5 nM (IKs in canine left ventricular myocytes), 34 nM (IKs in guinea pig left ventricular myocytes)[1]
In Vitro	HMR 1556 inhibits Ito, ICa,L and IKr with IC50s of 33.9 μM, 27.5 μM, 12.6 μM in canine left ventricular myocytes, respectively[1].
References	[1]. Thomas GP, et al. HMR 1556, a potent and selective blocker of slowly activating delayed rectifier potassium current. J Cardiovasc Pharmacol. 2003 Jan;41(1):140-7. [2]. Gerlach U,et al. Synthesis and activity of novel and selective I(Ks)-channel blockers. J Med Chem. 2001 Nov 8;44(23):3831-7.

Molecular Formula	C₁₇H₂₄F₃NO₅S
Molecular Weight	411.44

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: HMR 1556
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Purity: 98.0%
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