223749-46-0

223749-46-0 structure

223749-46-0 structure

Name: HMR 1556
Chemical Name: HMR 1556
CAS Number: 223749-46-0
Molecular Formula: C₁₇H₂₄F₃NO₅S
Molecular Weight: 411.44
Catalog: Signaling Pathways Membrane Transporter/Ion Channel Potassium Channel
Create Date: 2019-06-02 20:41:23
Modify Date: 2024-01-10 13:43:55
HMR 1556, a chromanol derivative, is a IKs blocker with IC50s of 10.5 nM and 34 nM in canine and guinea pig left ventricular myocytes, respectively[1][2].

Name	HMR 1556

Description	HMR 1556, a chromanol derivative, is a IKs blocker with IC50s of 10.5 nM and 34 nM in canine and guinea pig left ventricular myocytes, respectively[1][2].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel
Target	IC50: 10.5 nM (IKs in canine left ventricular myocytes), 34 nM (IKs in guinea pig left ventricular myocytes)[1]
In Vitro	HMR 1556 inhibits Ito, ICa,L and IKr with IC50s of 33.9 μM, 27.5 μM, 12.6 μM in canine left ventricular myocytes, respectively[1].
References	[1]. Thomas GP, et al. HMR 1556, a potent and selective blocker of slowly activating delayed rectifier potassium current. J Cardiovasc Pharmacol. 2003 Jan;41(1):140-7. [2]. Gerlach U,et al. Synthesis and activity of novel and selective I(Ks)-channel blockers. J Med Chem. 2001 Nov 8;44(23):3831-7.

Molecular Formula	C₁₇H₂₄F₃NO₅S
Molecular Weight	411.44