FAK inhibitor 5
Modify Date: 2023-01-14 10:58:11
FAK inhibitor 5 structure
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Common Name | FAK inhibitor 5 | ||
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| CAS Number | 2237234-47-6 | Molecular Weight | 575.026 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C28H27ClN8O4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of FAK inhibitor 5FAK inhibitor 5 is the first highly potent, selective irreversible inhibitor of the FAK kinase with IC50 of 0.6 nM; displays little to no inhibition against a panel of ten kinases (EGFR, HER2/ERBB2, IGF1R, c-Kit, PDGFR, Pyk2, c-Src, IRR, and IR); dose-dependently inhibits the proliferation with ED50 of 1.73 uM in SCC cells, blocks Tyr397 phosphorylation in a dose-dependent manner and significantly inhibits FAK autophosphorylation at low concentrations. |
| Name | FAK inhibitor 5 |
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| Description | FAK inhibitor 5 is the first highly potent, selective irreversible inhibitor of the FAK kinase with IC50 of 0.6 nM; displays little to no inhibition against a panel of ten kinases (EGFR, HER2/ERBB2, IGF1R, c-Kit, PDGFR, Pyk2, c-Src, IRR, and IR); dose-dependently inhibits the proliferation with ED50 of 1.73 uM in SCC cells, blocks Tyr397 phosphorylation in a dose-dependent manner and significantly inhibits FAK autophosphorylation at low concentrations. |
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| References | References 1. Yen-Pon E, et al. ACS Chem Biol. 2018 Jun 13. doi: 10.1021/acschembio.8b00250. View Related Products by Target Focal Adhesion Kinase (FAK) |
| Molecular Formula | C28H27ClN8O4 |
|---|---|
| Molecular Weight | 575.026 |