NCT-505
Modify Date: 2025-10-08 15:30:23
NCT-505 structure
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Common Name | NCT-505 | ||
|---|---|---|---|---|
| CAS Number | 2231079-75-5 | Molecular Weight | 635.635 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C29H29F4N5O5S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of NCT-505NCT-505 (NCT505) is a potent, selective, orally available ALDH1A1 inhibitor with IC50 of 7 nM (hALDH1A1), exhibits high specificity over other ALDH isozymes and unrelated dehydrogenases; also exhibits IC50 of 30 nM in MIA PaCa-2 Aldefluor cell-based assays; demonstrates target engagement in CETSA asssay (EC50=3.4 uM), inhibits the formation of 3D spheroid cultures of OV-90 cancer cells, and potentiates the cytotoxicity of Paclitaxel in SKOV-3-TR, a Paclitaxel resistant ovarian cancer cell line. |
| Name | NCT-505 |
|---|
| Description | NCT-505 (NCT505) is a potent, selective, orally available ALDH1A1 inhibitor with IC50 of 7 nM (hALDH1A1), exhibits high specificity over other ALDH isozymes and unrelated dehydrogenases; also exhibits IC50 of 30 nM in MIA PaCa-2 Aldefluor cell-based assays; demonstrates target engagement in CETSA asssay (EC50=3.4 uM), inhibits the formation of 3D spheroid cultures of OV-90 cancer cells, and potentiates the cytotoxicity of Paclitaxel in SKOV-3-TR, a Paclitaxel resistant ovarian cancer cell line. |
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| References | References 1. Yang SM, et al. J Med Chem. 2018 Jun 14;61(11):4883-4903. View Related Products by Target Aldehyde Dehydrogenase (ALDH) |
| Molecular Formula | C29H29F4N5O5S |
|---|---|
| Molecular Weight | 635.635 |
| InChIKey | ORKCVWNLHVYALZ-UHFFFAOYSA-N |
| SMILES | CS(=O)(=O)N1CCN(C(=O)c2cnc3ccc(F)cc3c2N2CCC(C#N)(c3ccccc3)CC2C(=O)C(F)(F)F)CC1 |