NCT-502
Modify Date: 2025-08-25 12:21:23
NCT-502 structure
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Common Name | NCT-502 | ||
|---|---|---|---|---|
| CAS Number | 1542213-00-2 | Molecular Weight | 395.45 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C18H20F3N5S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of NCT-502NCT-502 is a human phosphoglycerate dehydrogenase (PHGDH) inhibitor, cytotoxic to PHGDH-dependent cancer cells, and reduces glucose-derived serine production, with an IC50 of 3.7 μM against PHGDH[1]. |
| Name | NCT-502 |
|---|
| Description | NCT-502 is a human phosphoglycerate dehydrogenase (PHGDH) inhibitor, cytotoxic to PHGDH-dependent cancer cells, and reduces glucose-derived serine production, with an IC50 of 3.7 μM against PHGDH[1]. |
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| Related Catalog | |
| Target |
IC50: 3.7 μM (PHGDH)[1] |
| In Vitro | NCT-502 is cytotoxic to MDA-MB-468, with an EC50 of 15.2 µM[1]. |
| References |
| Molecular Formula | C18H20F3N5S |
|---|---|
| Molecular Weight | 395.45 |
| InChIKey | HHKPPMSUPATMKP-UHFFFAOYSA-N |
| SMILES | Cc1cc(C)nc(NC(=S)N2CCN(c3ccc(C(F)(F)F)cn3)CC2)c1 |
| Storage condition | 2-8℃ |