Loreclezole hydrochloride

Modify Date: 2025-08-27 01:18:48

Loreclezole hydrochloride structure	Common Name	Loreclezole hydrochloride
	CAS Number	2227372-56-5	Molecular Weight	310.99
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₀H₇Cl₄N₃	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Loreclezole hydrochloride

Loreclezole hydrochloride, an antiepileptic compound, is a selective GABAA receptor modulator and acts as a positive allosteric modulator of β2 or β3-subunit containing receptors[1][2].

Name	Loreclezole hydrochloride

Description	Loreclezole hydrochloride, an antiepileptic compound, is a selective GABAA receptor modulator and acts as a positive allosteric modulator of β2 or β3-subunit containing receptors[1][2].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor Research Areas >> Neurological Disease Signaling Pathways >> Neuronal Signaling >> GABA Receptor
Target	GABAA receptor[1].
In Vivo	Loreclezole (10, 25, 50 or 75 mg/kg, i.p. 60 min before measurement of seizure threshold ) results in a dosedependent rise in seizure threshold as measured by the dose of pentylenetetrazolrequired to produce a convulsion 60 min later. Loreclezole also has the least effect on loss of muscle tone as measured by the “pull-up” test[3]. Animal Model: Adult male Lister Hooded rats[3]. Dosage: 10, 25, 50 or 75 mg/kg. Administration: IP, 60 min before measurement of seizure threshold. Result: Resulted in a dosedependent rise in seizure threshold as measured by the dose of pentylenetetrazolrequired to produce a convulsion 60 min later.
References	[1]. Wingrove PB, et al. The modulatory action of loreclezole at the gamma-aminobutyric acid type A receptor is determined by a single amino acid in the beta 2 and beta 3 subunit. Proc Natl Acad Sci U S A. 1994 May 10;91(10):4569-73. [2]. Sanna E, et al. Direct activation of GABAA receptors by loreclezole, an anticonvulsant drug with selectivity for the beta-subunit. Neuropharmacology. 1996;35(12):1753-60. [3]. Green AR, et al. A behavioural and neurochemical study in rats of the pharmacology of loreclezole, a novel allosteric modulator of the GABAA receptor. Neuropharmacology. 1996;35(9-10):1243-50.

Molecular Formula	C₁₀H₇Cl₄N₃
Molecular Weight	310.99
InChIKey	AWKSVFLKVCVVFQ-MDZFRNKHSA-N
SMILES	Cl.ClC(=Cn1cncn1)c1ccc(Cl)cc1Cl

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