JMI-105

Modify Date: 2024-04-06 10:51:11

JMI-105 structure	Common Name	JMI-105
	CAS Number	2227315-30-0	Molecular Weight	337.42
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₀H₂₃N₃O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of JMI-105

JMI-105 is a potent PfFP-2 (Plasmodium falciparum falcipain-2 protease) inhibitor. JMI-105 inhibits the growth of CQS (3D7; IC50=8.8 µM) and CQR (RKL-9; IC50=14.3 µM) strains of P. falciparum. JMI-105 significantly decreases parasitemia and prolonged host survival in a murine model with P. berghei ANKA infection. JMI-105 has the potential to be used as an anti-malarial agent[1].

Name	JMI-105

Description	JMI-105 is a potent PfFP-2 (Plasmodium falciparum falcipain-2 protease) inhibitor. JMI-105 inhibits the growth of CQS (3D7; IC50=8.8 µM) and CQR (RKL-9; IC50=14.3 µM) strains of P. falciparum. JMI-105 significantly decreases parasitemia and prolonged host survival in a murine model with P. berghei ANKA infection. JMI-105 has the potential to be used as an anti-malarial agent[1].
Related Catalog	Research Areas >> Infection
References	[1]. Uddin A, et al. Identification and structure-activity relationship (SAR) studies of carvacrol derivatives as potential anti-malarial against Plasmodium falciparum falcipain-2 protease. Bioorg Chem. 2020 Oct;103:104142.

Molecular Formula	C₂₀H₂₃N₃O₂
Molecular Weight	337.42

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JMI-105

Use of JMI-105

Names

JMI-105 Biological Activity

Chemical & Physical Properties

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.