STAT3 inhibitor N4
Modify Date: 2024-04-01 23:02:34
STAT3 inhibitor N4 structure
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Common Name | STAT3 inhibitor N4 | ||
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| CAS Number | 2225879-93-4 | Molecular Weight | 465.553 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C29H27N3O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of STAT3 inhibitor N4STAT3 inhibitor N4 is a small molecule capable of inhibiting the STAT3 SH2 domain with IC50 of 0.57 uM, SPR KD of 1.04 uM, inhibits STAT3 dimerization and transcription in vitro and suppresses pancreatic cancer in vivo.N4 suppresses STAT3 activation in pancreatic cancer cells, suppresses pancreatic cancer cell growth, migration, and induces apoptosis.N4 (20 mg/kg, i.p.) suppresses pancreatic cancer growth, exhibits potent anti-metastatic activity in a pancreatic cancer liver metastasis mouse model, and prolongs survival of tumor-bearing mice. |
| Name | STAT3 inhibitor N4 |
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| Description | STAT3 inhibitor N4 is a small molecule capable of inhibiting the STAT3 SH2 domain with IC50 of 0.57 uM, SPR KD of 1.04 uM, inhibits STAT3 dimerization and transcription in vitro and suppresses pancreatic cancer in vivo.N4 suppresses STAT3 activation in pancreatic cancer cells, suppresses pancreatic cancer cell growth, migration, and induces apoptosis.N4 (20 mg/kg, i.p.) suppresses pancreatic cancer growth, exhibits potent anti-metastatic activity in a pancreatic cancer liver metastasis mouse model, and prolongs survival of tumor-bearing mice. |
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| References | 1. Huang Chen, et al. Oncogene. 2021 Feb;40(8):1440-1457. |
| Molecular Formula | C29H27N3O3 |
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| Molecular Weight | 465.553 |