GLPG-3221

Modify Date: 2024-01-11 14:13:42

GLPG-3221 structure	Common Name	GLPG-3221
	CAS Number	2222264-64-2	Molecular Weight	578.62
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₃₀H₃₇F₃N₂O₆	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of GLPG-3221

GLPG-3221 is a potent, orally active corrector of CFTR (cystic fibrosis transmembrane conductance regulator), with an EC50 of 105 nM. GLPG-3221 can be uesd for the treatment of cystic fibrosis[1].

Name	GLPG-3221

Description	GLPG-3221 is a potent, orally active corrector of CFTR (cystic fibrosis transmembrane conductance regulator), with an EC50 of 105 nM. GLPG-3221 can be uesd for the treatment of cystic fibrosis[1].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> CFTR Research Areas >> Others
In Vivo	GLPG-3221 (1 mg/kg; i.v.) treatment shows the Cl and t1/2 are 0.13 L/h/kg and 3 hours, respectively[1]. GLPG-3221 (1 mg/kg; p.o.)treatment shows the F% value is 53%[1]. Animal Model: Rat[1] Dosage: 1 mg/kg Administration: i.v. administration (Pharmacokinetic Analysis) Result: The Cl and t1/2 were 0.13 L/h/kg and 3 hours, respectively.
References	[1]. Scanio MJC, et al.Discovery of ABBV/GLPG-3221, a Potent Corrector of CFTR for the Treatment of Cystic Fibrosis.ACS Med Chem Lett. 2019 Oct 31;10(11):1543-1548.

Molecular Formula	C₃₀H₃₇F₃N₂O₆
Molecular Weight	578.62

DC Chemicals Limited
China
Product Name: GLPG-3221
Price:
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

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