2222264-64-2
2222264-64-2 structure
- Name: GLPG-3221
- Chemical Name: GLPG-3221
- CAS Number: 2222264-64-2
- Molecular Formula: C30H37F3N2O6
- Molecular Weight: 578.62
- Catalog: Signaling Pathways Membrane Transporter/Ion Channel CFTR
- Create Date: 2020-04-04 16:54:35
- Modify Date: 2024-01-11 14:13:42
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GLPG-3221 is a potent, orally active corrector of CFTR (cystic fibrosis transmembrane conductance regulator), with an EC50 of 105 nM. GLPG-3221 can be uesd for the treatment of cystic fibrosis[1].
| Name | GLPG-3221 |
|---|
| Description | GLPG-3221 is a potent, orally active corrector of CFTR (cystic fibrosis transmembrane conductance regulator), with an EC50 of 105 nM. GLPG-3221 can be uesd for the treatment of cystic fibrosis[1]. |
|---|---|
| Related Catalog | |
| In Vivo | GLPG-3221 (1 mg/kg; i.v.) treatment shows the Cl and t1/2 are 0.13 L/h/kg and 3 hours, respectively[1]. GLPG-3221 (1 mg/kg; p.o.)treatment shows the F% value is 53%[1]. Animal Model: Rat[1] Dosage: 1 mg/kg Administration: i.v. administration (Pharmacokinetic Analysis) Result: The Cl and t1/2 were 0.13 L/h/kg and 3 hours, respectively. |
| References |
| Molecular Formula | C30H37F3N2O6 |
|---|---|
| Molecular Weight | 578.62 |