Valategrast
Modify Date: 2025-08-27 21:57:26
Valategrast structure
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Common Name | Valategrast | ||
|---|---|---|---|---|
| CAS Number | 220847-86-9 | Molecular Weight | 604.95200 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C30H32Cl3N3O4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of ValategrastValategrast (R-411 free base) is a potent and orally active integrin α4β1 (VLA-4) and α4β7 dual antagonist. Valategrast has the potential for Chronic obstructive pulmonary disease (COPD) and asthma treatment[1][2]. |
| Name | 2-(Diethylamino)ethyl N-(2-chloro-6-methylbenzoyl)-4-[(2,6-dichlo robenzoyl)amino]-L-phenylalaninate |
|---|---|
| Synonym | More Synonyms |
| Description | Valategrast (R-411 free base) is a potent and orally active integrin α4β1 (VLA-4) and α4β7 dual antagonist. Valategrast has the potential for Chronic obstructive pulmonary disease (COPD) and asthma treatment[1][2]. |
|---|---|
| Related Catalog | |
| Target |
Integrin α4β1; Integrin α4β7[2] |
| In Vitro | Valategrast contains a common l-phenylalanine-N-aroyl motif where the carboxylic acid is responsible for binding to the metal ion in the metal-ion-dependent adhesion site (MIDAS)[2]. |
| References |
| Molecular Formula | C30H32Cl3N3O4 |
|---|---|
| Molecular Weight | 604.95200 |
| Exact Mass | 603.14600 |
| PSA | 91.23000 |
| LogP | 7.08140 |
| Valategrast (R411) |