Valategrast

Names

[ CAS No. ]:
220847-86-9

[ Name ]:
Valategrast

[Synonym ]:
Valategrast (R411)

Biological Activity

[Description]:

Valategrast (R-411 free base) is a potent and orally active integrin α4β1 (VLA-4) and α4β7 dual antagonist. Valategrast has the potential for Chronic obstructive pulmonary disease (COPD) and asthma treatment[1][2].

[Related Catalog]:

Research Areas >> Inflammation/Immunology

Signaling Pathways >> Cytoskeleton >> Integrin

[Target]

Integrin α4β1; Integrin α4β7[2]

[In Vitro]

Valategrast contains a common l-phenylalanine-N-aroyl motif where the carboxylic acid is responsible for binding to the metal ion in the metal-ion-dependent adhesion site (MIDAS)[2].

[References]

[1]. Woodside DG, et al. Cell adhesion antagonists: therapeutic potential in asthma and chronic obstructive pulmonary disease. BioDrugs. 2008;22(2):85-100.

[2]. Halland N, et al. Small Macrocycles As Highly Active Integrin α2β1 Antagonists. ACS Med Chem Lett. 2014 Jan 10;5(2):193-8.

Chemical & Physical Properties

[ Molecular Formula ]:
C₃₀H₃₂Cl₃N₃O₄

[ Molecular Weight ]:
604.95200

[ Exact Mass ]:
603.14600

[ PSA ]:
91.23000

[ LogP ]:
7.08140

Related Compounds

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