Valategrast hydrochloride
Modify Date: 2024-01-12 16:15:49
Valategrast hydrochloride structure
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Common Name | Valategrast hydrochloride | ||
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| CAS Number | 828271-96-1 | Molecular Weight | 641.41300 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C30H33Cl4N3O4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Valategrast hydrochlorideValategrast hydrochloride (R-411) is a potent integrin α4β1 (VLA-4) and α4β7 dual antagonist. Valategrast hydrochloride has the potential for Chronic obstructive pulmonary disease (COPD) and asthma treatment[1][2]. |
| Name | 2-(Diethylamino)ethyl N-(2-chloro-6-methylbenzoyl)-4-[(2,6-dichlo robenzoyl)amino]-L-phenylalaninate hydrochloride (1:1) |
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| Description | Valategrast hydrochloride (R-411) is a potent integrin α4β1 (VLA-4) and α4β7 dual antagonist. Valategrast hydrochloride has the potential for Chronic obstructive pulmonary disease (COPD) and asthma treatment[1][2]. |
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| Related Catalog | |
| Target |
α4β1 α4β7 |
| In Vitro | Valategrast (hydrochloride) contains a common l-phenylalanine-N-aroyl motif where the carboxylic acid is responsible for binding to the metal ion in the metal-ion-dependent adhesion site (MIDAS)[2]. |
| References |
| Molecular Formula | C30H33Cl4N3O4 |
|---|---|
| Molecular Weight | 641.41300 |
| Exact Mass | 639.12300 |
| PSA | 91.23000 |
| LogP | 7.88340 |