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Valategrast hydrochloride

Names

[ CAS No. ]:
828271-96-1

[ Name ]:
Valategrast hydrochloride

Biological Activity

[Description]:

Valategrast hydrochloride (R-411) is a potent integrin α4β1 (VLA-4) and α4β7 dual antagonist. Valategrast hydrochloride has the potential for Chronic obstructive pulmonary disease (COPD) and asthma treatment[1][2].

[Related Catalog]:

Research Areas >> Inflammation/Immunology
Signaling Pathways >> Cytoskeleton >> Integrin

[Target]

α4β1

α4β7


[In Vitro]

Valategrast (hydrochloride) contains a common l-phenylalanine-N-aroyl motif where the carboxylic acid is responsible for binding to the metal ion in the metal-ion-dependent adhesion site (MIDAS)[2].

[References]

[1]. Woodside DG, et al. Cell adhesion antagonists: therapeutic potential in asthma and chronic obstructive pulmonary disease. BioDrugs. 2008;22(2):85-100.

[2]. Halland N, et al. Small Macrocycles As Highly Active Integrin α2β1 Antagonists. ACS Med Chem Lett. 2014 Jan 10;5(2):193-8.

Chemical & Physical Properties

[ Molecular Formula ]:
C30H33Cl4N3O4

[ Molecular Weight ]:
641.41300

[ Exact Mass ]:
639.12300

[ PSA ]:
91.23000

[ LogP ]:
7.88340

Related Compounds