FzM1.8
Modify Date: 2024-09-19 12:52:25
FzM1.8 structure
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Common Name | FzM1.8 | ||
|---|---|---|---|---|
| CAS Number | 2204290-85-5 | Molecular Weight | 322.31 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C18H14N2O4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of FzM1.8FzM1.8 derives from FzM1, is an allosteric agonist of FZD4 with pEC50 of 6.4. FzM1.8 binds to FZD4 and activates the WNT/β-catenin pathway, by promoting TCF/LEF transcriptional activity in the absence of any WNT ligand. FzM1.8 binding stabilizes FZD4 with an increased affinity for heterotrimeric G protein and stimulates the release of the Gβγ subunit that in turn activates PI3K[1]. |
| Name | FzM1.8 |
|---|
| Description | FzM1.8 derives from FzM1, is an allosteric agonist of FZD4 with pEC50 of 6.4. FzM1.8 binds to FZD4 and activates the WNT/β-catenin pathway, by promoting TCF/LEF transcriptional activity in the absence of any WNT ligand. FzM1.8 binding stabilizes FZD4 with an increased affinity for heterotrimeric G protein and stimulates the release of the Gβγ subunit that in turn activates PI3K[1]. |
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| Related Catalog | |
| Target |
pEC50: 6.4 (FzM1.8)[1] |
| References |
| Molecular Formula | C18H14N2O4 |
|---|---|
| Molecular Weight | 322.31 |
| InChIKey | XGNNCRZDDAJBFU-UHFFFAOYSA-N |
| SMILES | O=C(Nc1cc(O)cc(C(=O)O)c1)Nc1ccc2ccccc2c1 |
| Storage condition | -20°C |