FzM1.8

Names

[ CAS No. ]:
2204290-85-5

[ Name ]:
FzM1.8

Biological Activity

[Description]:

FzM1.8 derives from FzM1, is an allosteric agonist of FZD4 with pEC50 of 6.4. FzM1.8 binds to FZD4 and activates the WNT/β-catenin pathway, by promoting TCF/LEF transcriptional activity in the absence of any WNT ligand. FzM1.8 binding stabilizes FZD4 with an increased affinity for heterotrimeric G protein and stimulates the release of the Gβγ subunit that in turn activates PI3K[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Stem Cell/Wnt >> Wnt

[Target]

pEC50: 6.4 (FzM1.8)[1]

[References]

[1]. Riccio G, et al. A Negative Allosteric Modulator of WNT Receptor Frizzled 4 Switches into an Allosteric Agonist. Biochemistry. 2018 Feb 6;57(5):839-851.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₈H₁₄N₂O₄

[ Molecular Weight ]:
322.31

[ Storage condition ]:
-20°C

Related Compounds

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