2204290-85-5

2204290-85-5 structure

Name: FzM1.8
Chemical Name: FzM1.8
CAS Number: 2204290-85-5
Molecular Formula: C₁₈H₁₄N₂O₄
Molecular Weight: 322.31
Catalog: Signaling Pathways Stem Cell/Wnt Wnt
Create Date: 2019-10-09 13:03:29
Modify Date: 2023-02-16 22:11:32
FzM1.8 derives from FzM1, is an allosteric agonist of FZD4 with pEC50 of 6.4. FzM1.8 binds to FZD4 and activates the WNT/β-catenin pathway, by promoting TCF/LEF transcriptional activity in the absence of any WNT ligand. FzM1.8 binding stabilizes FZD4 with an increased affinity for heterotrimeric G protein and stimulates the release of the Gβγ subunit that in turn activates PI3K[1].

Name	FzM1.8

Description	FzM1.8 derives from FzM1, is an allosteric agonist of FZD4 with pEC50 of 6.4. FzM1.8 binds to FZD4 and activates the WNT/β-catenin pathway, by promoting TCF/LEF transcriptional activity in the absence of any WNT ligand. FzM1.8 binding stabilizes FZD4 with an increased affinity for heterotrimeric G protein and stimulates the release of the Gβγ subunit that in turn activates PI3K[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Stem Cell/Wnt >> Wnt
Target	pEC50: 6.4 (FzM1.8)[1]
References	[1]. Riccio G, et al. A Negative Allosteric Modulator of WNT Receptor Frizzled 4 Switches into an Allosteric Agonist. Biochemistry. 2018 Feb 6;57(5):839-851.