DH 97

Modify Date: 2024-01-21 15:24:07

DH 97 structure	Common Name	DH 97
	CAS Number	220339-00-4	Molecular Weight	334.455
	Density	1.1±0.1 g/cm3	Boiling Point	580.1±38.0 °C at 760 mmHg
	Molecular Formula	C₂₂H₂₆N₂O	Melting Point	N/A
	MSDS	N/A	Flash Point	304.6±26.8 °C

Use of DH 97

DH97 is a potent and selective antagonist of MT2 melatonin receptor, with a pKi of 8.03 for human MT2. DH97 shows 89- and 229-fold selectivity for human MT2 over human mt1 and Xenopus mel1c receptor subtypes. DH97 can inhibit melatonin-induced enhancement of electrically-evoked responses[1][2].

Name	DH97
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Description	DH97 is a potent and selective antagonist of MT2 melatonin receptor, with a pKi of 8.03 for human MT2. DH97 shows 89- and 229-fold selectivity for human MT2 over human mt1 and Xenopus mel1c receptor subtypes. DH97 can inhibit melatonin-induced enhancement of electrically-evoked responses[1][2].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> Melatonin Receptor Signaling Pathways >> GPCR/G Protein >> Melatonin Receptor Research Areas >> Neurological Disease
Target	MT2:8.03 (pKi) MT1:6.08 (pKi)
In Vitro	DH97 (compound 9) (0.1-100 μM; 2 h) antagonizes pigment aggregation induced by melatonin (10 nM) in Xenopus laevis melanophores[1]. DH97 has no agonist activity at concentrations up to 100 µM[1]. DH97 (60 nM) significantly alteres the potency of melatonin in the rat tail artery at low concentrations of the MT2 selective ligands, with a pEC50 of 8.83[2]. DH97 (5 μM) causes a significant rightward displacement of the vasoconstrictor effect of melatonin at concentrations non-selective for mt1 and MT2 receptors[2].
References	[1]. Teh MT, et, al. Comparison of the structure-activity relationships of melatonin receptor agonists and antagonists: lengthening the N-acyl side-chain has differing effects on potency on Xenopus melanophores. Naunyn Schmiedebergs Arch Pharmacol. 1998 Nov;358(5):522-8. [2]. Ting KN, et, al. Molecular and pharmacological evidence for MT1 melatonin receptor subtype in the tail artery of juvenile Wistar rats. Br J Pharmacol. 1999 Jun;127(4):987-95.

Density	1.1±0.1 g/cm3
Boiling Point	580.1±38.0 °C at 760 mmHg
Molecular Formula	C₂₂H₂₆N₂O
Molecular Weight	334.455
Flash Point	304.6±26.8 °C
Exact Mass	334.204498
LogP	4.63
Vapour Pressure	0.0±1.6 mmHg at 25°C
Index of Refraction	1.605

Pentanamide, N-[2-[2-(phenylmethyl)-1H-indol-3-yl]ethyl]-

N-(2-(2-Benzyl-1H-indol-3-yl)ethyl)pentanamide

N-[2-(2-Benzyl-1H-indol-3-yl)ethyl]pentanamide

DH97

MFCD02262121

DC Chemicals Limited
China
Product Name: DH97
Price: ￥Inquiry/1g
Purity: 98.9%
Stocking Period: 1 Day
Contact: Tony Cao

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