Glucagon receptor antagonists-5

Modify Date: 2024-02-12 19:23:38

Glucagon receptor antagonists-5 Structure
Glucagon receptor antagonists-5 structure
Common Name Glucagon receptor antagonists-5
CAS Number 2200274-63-9 Molecular Weight 572.02
Density N/A Boiling Point N/A
Molecular Formula C30H29ClF3N3O3 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Glucagon receptor antagonists-5


Glucagon receptor antagonists-5 (compound 13K) is a potent and orally bioavailable indazole-based glucagon receptor antagonist (Ki=32 nM). Glucagon receptor antagonists-5 has potential for the treatment of type 2 diabetes mellitus (T2DM)[1].

 Names

Name Glucagon receptor antagonists-5

 Glucagon receptor antagonists-5 Biological Activity

Description Glucagon receptor antagonists-5 (compound 13K) is a potent and orally bioavailable indazole-based glucagon receptor antagonist (Ki=32 nM). Glucagon receptor antagonists-5 has potential for the treatment of type 2 diabetes mellitus (T2DM)[1].
Target

Ki: 32 nM (glucagon receptor)[1]

References

[1]. Xu G, et al. Discovery of potent and orally bioavailable indazole-based glucagon receptor antagonists for the treatment of type 2 diabetes. Bioorg Med Chem Lett. 2019 Oct 15;29(20):126668.

 Chemical & Physical Properties

Molecular Formula C30H29ClF3N3O3
Molecular Weight 572.02