AZ1495
Modify Date: 2024-01-16 15:33:55
AZ1495 structure
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Common Name | AZ1495 | ||
|---|---|---|---|---|
| CAS Number | 2196204-23-4 | Molecular Weight | 385.50 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C21H31N5O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of AZ1495AZ1495 (compound 28) is an oral active inhibitor of Interleukin-1 receptor associated kinase 4 (IRAK4), with IC50 values of 5 nM and 23 nM for IRAK4 and IRAK1, respectively. Shows activity in treatment of mutant MYD88L265P diffuse large B-cell lymphoma (DLBCL)[1]. |
| Name | AZ1495 |
|---|
| Description | AZ1495 (compound 28) is an oral active inhibitor of Interleukin-1 receptor associated kinase 4 (IRAK4), with IC50 values of 5 nM and 23 nM for IRAK4 and IRAK1, respectively. Shows activity in treatment of mutant MYD88L265P diffuse large B-cell lymphoma (DLBCL)[1]. |
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| Related Catalog | |
| Target |
IRAK4:5 nM (IC50) IRAK1:23 nM (IC50) CLK1:50 nM (IC50) CLK2:5 nM (IC50) CLK4:8 nM (IC50) haspin:4 nM (IC50) |
| References |
| Molecular Formula | C21H31N5O2 |
|---|---|
| Molecular Weight | 385.50 |
| Storage condition | 2-8℃ |