2196204-23-4

2196204-23-4 structure

Name: AZ1495
Chemical Name: AZ1495
CAS Number: 2196204-23-4
Molecular Formula: C₂₁H₃₁N₅O₂
Molecular Weight: 385.50
Catalog: Signaling Pathways Immunology/Inflammation IRAK
Create Date: 2019-03-31 07:15:34
Modify Date: 2024-01-16 15:33:55
AZ1495 (compound 28) is an oral active inhibitor of Interleukin-1 receptor associated kinase 4 (IRAK4), with IC50 values of 5 nM and 23 nM for IRAK4 and IRAK1, respectively. Shows activity in treatment of mutant MYD88L265P diffuse large B-cell lymphoma (DLBCL)[1].

Name	AZ1495

Description	AZ1495 (compound 28) is an oral active inhibitor of Interleukin-1 receptor associated kinase 4 (IRAK4), with IC50 values of 5 nM and 23 nM for IRAK4 and IRAK1, respectively. Shows activity in treatment of mutant MYD88L265P diffuse large B-cell lymphoma (DLBCL)[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Immunology/Inflammation >> IRAK Signaling Pathways >> Protein Tyrosine Kinase/RTK >> IRAK
Target	IRAK4:5 nM (IC50) IRAK1:23 nM (IC50) CLK1:50 nM (IC50) CLK2:5 nM (IC50) CLK4:8 nM (IC50) haspin:4 nM (IC50)
References	[1]. Scott JS, et al. Discovery and Optimization of Pyrrolopyrimidine Inhibitors of Interleukin-1 Receptor Associated Kinase 4 (IRAK4) for the Treatment of Mutant MYD88L265P Diffuse Large B-Cell Lymphoma. J Med Chem. 2017 Dec 28;60(24):10071-10091.