AZ1495

Names

[ CAS No. ]:
2196204-23-4

[ Name ]:
AZ1495

Biological Activity

[Description]:

AZ1495 (compound 28) is an oral active inhibitor of Interleukin-1 receptor associated kinase 4 (IRAK4), with IC50 values of 5 nM and 23 nM for IRAK4 and IRAK1, respectively. Shows activity in treatment of mutant MYD88L265P diffuse large B-cell lymphoma (DLBCL)[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Immunology/Inflammation >> IRAK

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> IRAK

[Target]

IRAK4:5 nM (IC50)

IRAK1:23 nM (IC50)

CLK1:50 nM (IC50)

CLK2:5 nM (IC50)

CLK4:8 nM (IC50)

haspin:4 nM (IC50)

[References]

[1]. Scott JS, et al. Discovery and Optimization of Pyrrolopyrimidine Inhibitors of Interleukin-1 Receptor Associated Kinase 4 (IRAK4) for the Treatment of Mutant MYD88L265P Diffuse Large B-Cell Lymphoma. J Med Chem. 2017 Dec 28;60(24):10071-10091.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₁H₃₁N₅O₂

[ Molecular Weight ]:
385.50

[ Storage condition ]:
2-8℃