APG-2449

Modify Date: 2025-10-13 08:02:37

APG-2449 structure	Common Name	APG-2449
	CAS Number	2196186-84-0	Molecular Weight	640.24
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₃₃H₄₂ClN₅O₄S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of APG-2449

APG-2449 is an orally active ALK/ROS1/FAK inhibitor. APG-2449 shows antitumor activity in mouse models of non-small cell lung cancer (NSCLC)[1].

Name	APG-2449

Description	APG-2449 is an orally active ALK/ROS1/FAK inhibitor. APG-2449 shows antitumor activity in mouse models of non-small cell lung cancer (NSCLC)[1].
Related Catalog	Research Areas >> Others Signaling Pathways >> Protein Tyrosine Kinase/RTK >> ROS Signaling Pathways >> Protein Tyrosine Kinase/RTK >> ALK Signaling Pathways >> Protein Tyrosine Kinase/RTK >> FAK
References	[1]. Fang DD, et al. Discovery of a novel ALK/ROS1/FAK inhibitor, APG-2449, in preclinical non-small cell lung cancer and ovarian cancer models. BMC Cancer. 2022 Jul 11;22(1):752.

Molecular Formula	C₃₃H₄₂ClN₅O₄S
Molecular Weight	640.24

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