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2196186-84-0

2196186-84-0 structure

2196186-84-0 structure

Name: APG-2449
Chemical Name: APG-2449
CAS Number: 2196186-84-0
Molecular Formula: C₃₃H₄₂ClN₅O₄S
Molecular Weight: 640.24
Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK ALK
Create Date: 2023-12-09 12:02:55
Modify Date: 2025-10-13 08:02:37
APG-2449 is an orally active ALK/ROS1/FAK inhibitor. APG-2449 shows antitumor activity in mouse models of non-small cell lung cancer (NSCLC)[1].

Name	APG-2449

Description	APG-2449 is an orally active ALK/ROS1/FAK inhibitor. APG-2449 shows antitumor activity in mouse models of non-small cell lung cancer (NSCLC)[1].
Related Catalog	Research Areas >> Others Signaling Pathways >> Protein Tyrosine Kinase/RTK >> ROS Signaling Pathways >> Protein Tyrosine Kinase/RTK >> ALK Signaling Pathways >> Protein Tyrosine Kinase/RTK >> FAK
References	[1]. Fang DD, et al. Discovery of a novel ALK/ROS1/FAK inhibitor, APG-2449, in preclinical non-small cell lung cancer and ovarian cancer models. BMC Cancer. 2022 Jul 11;22(1):752.

Molecular Formula	C₃₃H₄₂ClN₅O₄S
Molecular Weight	640.24

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