Estrogen receptor modulator 8

Modify Date: 2024-01-14 10:04:19

Estrogen receptor modulator 8 Structure
Estrogen receptor modulator 8 structure
 Common Name Estrogen receptor modulator 8
CAS Number 2170766-56-8 Molecular Weight 460.46
Density N/A Boiling Point N/A
Molecular Formula C25H24F4N2O2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Estrogen receptor modulator 8


Estrogen receptor modulator 8 (compound 4) is an orally active inhibitor of Estrogen Receptor/ERR α (IC50=0.437 nM, MCF-7 cells). Estrogen receptor modulator 8 inhibits MCF-7 cells proliferation with an IC50 value of 0.1 nM[1].

 Names

Name Estrogen receptor modulator 8

 Estrogen receptor modulator 8 Biological Activity

Description Estrogen receptor modulator 8 (compound 4) is an orally active inhibitor of Estrogen Receptor/ERR α (IC50=0.437 nM, MCF-7 cells). Estrogen receptor modulator 8 inhibits MCF-7 cells proliferation with an IC50 value of 0.1 nM[1].
Related Catalog
Target

IC50: 0.437 nM (ERR α in MCF-7 cells)

References

[1]. Guan D, et al. Preparation of 3-[4-(tetrahydro-1H-pyrrolo[3,4-b]indol-1-yl)phenyl]acrylic acid compound useful as estrogen receptor down-regulator (SERD). World Intellectual Property Organization, WO2018001232 A1. 2018-01-04.

 Chemical & Physical Properties

Molecular Formula C25H24F4N2O2
Molecular Weight 460.46
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