Estrogen receptor modulator 8

Names

[ CAS No. ]:
2170766-56-8

[ Name ]:
Estrogen receptor modulator 8

Biological Activity

[Description]:

Estrogen receptor modulator 8 (compound 4) is an orally active inhibitor of Estrogen Receptor/ERR α (IC50=0.437 nM, MCF-7 cells). Estrogen receptor modulator 8 inhibits MCF-7 cells proliferation with an IC50 value of 0.1 nM[1].

[Related Catalog]:

Signaling Pathways >> Others >> Estrogen Receptor/ERR
Research Areas >> Endocrinology

[Target]

IC50: 0.437 nM (ERR α in MCF-7 cells)


[References]

[1]. Guan D, et al. Preparation of 3-[4-(tetrahydro-1H-pyrrolo[3,4-b]indol-1-yl)phenyl]acrylic acid compound useful as estrogen receptor down-regulator (SERD). World Intellectual Property Organization, WO2018001232 A1. 2018-01-04.

Chemical & Physical Properties

[ Molecular Formula ]:
C25H24F4N2O2

[ Molecular Weight ]:
460.46

Related Compounds

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