(Rac)-GSK-3484862

(Rac)-GSK-3484862 Structure
(Rac)-GSK-3484862 structure
Common Name (Rac)-GSK-3484862
CAS Number 2170136-02-2 Molecular Weight 365.45
Density N/A Boiling Point N/A
Molecular Formula C19H19N5OS Melting Point N/A
MSDS N/A Flash Point N/A

 Use of (Rac)-GSK-3484862


(Rac)-GSK-3484862 is the inactive isomer of GSK-3484862 (HY-135146), and can be used as an experimental control. GSK-3484862 is a non-covalent inhibitor for DNA methyltransferase (Dnmt1). GSK-3484862 induces DNA hypomethylation to against cancer. GSK-3484862 mediates dramatic demethylation in murine embryonic stem cells with minimal non-specific toxicity[1][2].

 Names

Name (Rac)-GSK-3484862

 (Rac)-GSK-3484862 Biological Activity

Description (Rac)-GSK-3484862 is the inactive isomer of GSK-3484862 (HY-135146), and can be used as an experimental control. GSK-3484862 is a non-covalent inhibitor for DNA methyltransferase (Dnmt1). GSK-3484862 induces DNA hypomethylation to against cancer. GSK-3484862 mediates dramatic demethylation in murine embryonic stem cells with minimal non-specific toxicity[1][2].
Related Catalog
References

[1]. Nathalia Azevedo Portilho, et al. The DNMT1 inhibitor GSK-3484862 mediates global demethylation in murine embryonic stem cells.

[2]. Keystone Symposia 2019 - Epigenetics and Human Disease

 Chemical & Physical Properties

Molecular Formula C19H19N5OS
Molecular Weight 365.45
InChIKey KIEQQZZDWUNUQK-UHFFFAOYSA-N
SMILES CCc1c(C#N)c(SC(C(N)=O)c2ccccc2)nc(N(C)C)c1C#N
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