(Rac)-GSK-3484862

Names

[ Name ]:
(Rac)-GSK-3484862

Biological Activity

[Description]:

(Rac)-GSK-3484862 is the inactive isomer of GSK-3484862 (HY-135146), and can be used as an experimental control. GSK-3484862 is a non-covalent inhibitor for DNA methyltransferase (Dnmt1). GSK-3484862 induces DNA hypomethylation to against cancer. GSK-3484862 mediates dramatic demethylation in murine embryonic stem cells with minimal non-specific toxicity[1][2].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[References]

[1]. Nathalia Azevedo Portilho, et al. The DNMT1 inhibitor GSK-3484862 mediates global demethylation in murine embryonic stem cells.

[2]. Keystone Symposia 2019 - Epigenetics and Human Disease

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₉H₁₉N₅OS

[ Molecular Weight ]:
365.45

Related Compounds

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