M‑89

Modify Date: 2024-01-03 15:37:48

M‑89 structure	Common Name	M‑89
	CAS Number	2145119-20-4	Molecular Weight	657.87
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₃₇H₄₇N₅O₄S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of M‑89

M-89 is a highly potent and specific menin inhibitor, with a Kd of 1.4 nM for binding to menin. M-89 inhibits the menin-mixed lineage leukemia (Menin-MLL) protein-protein interaction and has potential to treat MLL leukemia[1].

Name	M‑89

Description	M-89 is a highly potent and specific menin inhibitor, with a Kd of 1.4 nM for binding to menin. M-89 inhibits the menin-mixed lineage leukemia (Menin-MLL) protein-protein interaction and has potential to treat MLL leukemia[1].
Related Catalog	Research Areas >> Cancer Research Areas >> Inflammation/Immunology Signaling Pathways >> Epigenetics >> Epigenetic Reader Domain
Target	Kd: 1.4 nM (menin)[1].
References	[1]. Aguilar A, et al. Structure-Based Discovery of M-89 as a Highly Potent Inhibitor of the Menin-Mixed Lineage Leukemia (Menin-MLL) Protein-Protein Interaction. J Med Chem. 2019 Jul 11;62(13):6015-6034.

Molecular Formula	C₃₇H₄₇N₅O₄S
Molecular Weight	657.87

M‑89

Use of M‑89

Names

M‑89 Biological Activity

Chemical & Physical Properties