2145119-20-4

2145119-20-4 structure

Name: M‑89
Chemical Name: M‑89
CAS Number: 2145119-20-4
Molecular Formula: C₃₇H₄₇N₅O₄S
Molecular Weight: 657.87
Catalog: Signaling Pathways Epigenetics Epigenetic Reader Domain
Create Date: 2019-08-03 19:08:58
Modify Date: 2024-01-03 15:37:48
M-89 is a highly potent and specific menin inhibitor, with a Kd of 1.4 nM for binding to menin. M-89 inhibits the menin-mixed lineage leukemia (Menin-MLL) protein-protein interaction and has potential to treat MLL leukemia[1].

Name	M‑89

Description	M-89 is a highly potent and specific menin inhibitor, with a Kd of 1.4 nM for binding to menin. M-89 inhibits the menin-mixed lineage leukemia (Menin-MLL) protein-protein interaction and has potential to treat MLL leukemia[1].
Related Catalog	Research Areas >> Cancer Research Areas >> Inflammation/Immunology Signaling Pathways >> Epigenetics >> Epigenetic Reader Domain
Target	Kd: 1.4 nM (menin)[1].
References	[1]. Aguilar A, et al. Structure-Based Discovery of M-89 as a Highly Potent Inhibitor of the Menin-Mixed Lineage Leukemia (Menin-MLL) Protein-Protein Interaction. J Med Chem. 2019 Jul 11;62(13):6015-6034.

Molecular Formula	C₃₇H₄₇N₅O₄S
Molecular Weight	657.87