Navitoclax-piperazine

Modify Date: 2024-01-02 13:48:45

Navitoclax-piperazine Structure
Navitoclax-piperazine structure
Common Name Navitoclax-piperazine
CAS Number 2143096-93-7 Molecular Weight 973.63
Density N/A Boiling Point N/A
Molecular Formula C47H56ClF3N6O5S3 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Navitoclax-piperazine


Navitoclax-piperazine (ABT-263-piperazine) is a B-cell lymphoma extra large (BCL-XL) inhibitor. Navitoclax-piperazine and a VHL ligand for the E3 ubiquitin ligase can be used in the synthesis of PROTAC DT2216 (HY-130604)[1].

 Names

Name Navitoclax-piperazine

 Navitoclax-piperazine Biological Activity

Description Navitoclax-piperazine (ABT-263-piperazine) is a B-cell lymphoma extra large (BCL-XL) inhibitor. Navitoclax-piperazine and a VHL ligand for the E3 ubiquitin ligase can be used in the synthesis of PROTAC DT2216 (HY-130604)[1].
Related Catalog
Target

Bcl-xL

References

[1]. Sajid Khan, et al. A selective BCL-XL PROTAC degrader achieves safe and potent antitumor activity. Nat Med 25, 1938–1947 (2019).

 Chemical & Physical Properties

Molecular Formula C47H56ClF3N6O5S3
Molecular Weight 973.63

 Safety Information

Hazard Codes Xi
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