LT-540-717

Modify Date: 2024-04-03 14:08:42

LT-540-717 structure	Common Name	LT-540-717
	CAS Number	2143089-35-2	Molecular Weight	456.50
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₄H₂₄N₈O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of LT-540-717

LT-540-717 (compound 32) is a potent FLT3 inhibitor (IC50=0.62 nM) with antiproliferative activity. LT-540-717 also inhibits several acquired FLT3 mutations, FLT3 (ITD, D835V), FLT3 (ITD, F691L), FLT3 (D835Y) and FLT3 (D835V). LT-540-717 has potential to be an anti-AML agent[1].

Name	LT-540-717

Description	LT-540-717 (compound 32) is a potent FLT3 inhibitor (IC50=0.62 nM) with antiproliferative activity. LT-540-717 also inhibits several acquired FLT3 mutations, FLT3 (ITD, D835V), FLT3 (ITD, F691L), FLT3 (D835Y) and FLT3 (D835V). LT-540-717 has potential to be an anti-AML agent[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Protein Tyrosine Kinase/RTK >> FLT3
References	[1]. Zhi Y, et al. Rational design of 4-((6-phenoxypyrimidin-4-yl)amino)-N-(4-(piperazin-1-yl)phenyl)-1H-pyrazole-3-carboxamide (LT-540-717) as orally bioavailable FLT3 inhibitor. Eur J Med Chem. 2023 Aug 5;256:115448.

Molecular Formula	C₂₄H₂₄N₈O₂
Molecular Weight	456.50

Shanghai Nianxing Industrial Co., Ltd
China
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LT-540-717

Use of LT-540-717

Names

LT-540-717 Biological Activity

Chemical & Physical Properties