LT-540-717

Names

[ CAS No. ]:
2143089-35-2

[ Name ]:
LT-540-717

Biological Activity

[Description]:

LT-540-717 (compound 32) is a potent FLT3 inhibitor (IC50=0.62 nM) with antiproliferative activity. LT-540-717 also inhibits several acquired FLT3 mutations, FLT3 (ITD, D835V), FLT3 (ITD, F691L), FLT3 (D835Y) and FLT3 (D835V). LT-540-717 has potential to be an anti-AML agent[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Protein Tyrosine Kinase/RTK >> FLT3

[References]

[1]. Zhi Y, et al. Rational design of 4-((6-phenoxypyrimidin-4-yl)amino)-N-(4-(piperazin-1-yl)phenyl)-1H-pyrazole-3-carboxamide (LT-540-717) as orally bioavailable FLT3 inhibitor. Eur J Med Chem. 2023 Aug 5;256:115448.  

Chemical & Physical Properties

[ Molecular Formula ]:
C24H24N8O2

[ Molecular Weight ]:
456.50

Related Compounds

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