2143089-35-2

2143089-35-2 structure

Name: LT-540-717
Chemical Name: LT-540-717
CAS Number: 2143089-35-2
Molecular Formula: C₂₄H₂₄N₈O₂
Molecular Weight: 456.50
Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK FLT3
Create Date: 2023-11-03 18:22:13
Modify Date: 2024-04-03 14:08:42
LT-540-717 (compound 32) is a potent FLT3 inhibitor (IC50=0.62 nM) with antiproliferative activity. LT-540-717 also inhibits several acquired FLT3 mutations, FLT3 (ITD, D835V), FLT3 (ITD, F691L), FLT3 (D835Y) and FLT3 (D835V). LT-540-717 has potential to be an anti-AML agent[1].

Name	LT-540-717

Description	LT-540-717 (compound 32) is a potent FLT3 inhibitor (IC50=0.62 nM) with antiproliferative activity. LT-540-717 also inhibits several acquired FLT3 mutations, FLT3 (ITD, D835V), FLT3 (ITD, F691L), FLT3 (D835Y) and FLT3 (D835V). LT-540-717 has potential to be an anti-AML agent[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Protein Tyrosine Kinase/RTK >> FLT3
References	[1]. Zhi Y, et al. Rational design of 4-((6-phenoxypyrimidin-4-yl)amino)-N-(4-(piperazin-1-yl)phenyl)-1H-pyrazole-3-carboxamide (LT-540-717) as orally bioavailable FLT3 inhibitor. Eur J Med Chem. 2023 Aug 5;256:115448.

Molecular Formula	C₂₄H₂₄N₈O₂
Molecular Weight	456.50