DDC-01-163
Modify Date: 2024-01-06 10:54:18
DDC-01-163 structure
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Common Name | DDC-01-163 | ||
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| CAS Number | 2140806-84-2 | Molecular Weight | 942.061 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C49H51N9O9S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of DDC-01-163DDC-01-163 is an allosteric EGFR degrader that selectively inhibit the proliferation of L858R/T790M (L/T) mutant Ba/F3 cells while leaving wildtype EGFR Ba/F3 cells unaffected;DDC-01-163 exhibited an acceptable biochemical potency with an IC50 value of 45 nM against EGFR L858R/T790M.DDC-01-163 is also effective against osimertinib-resistant cells with L/T/C797S and L/T/L718Q EGFR mutations.The anti-proliferative activity of DDC-01-163 against L858R/T790M EGFR-Ba/F3 cells is enhanced when combined with an ATP-site EGFR inhibitor, Osimertinib. |
| Name | DDC-01-163 |
|---|
| Description | DDC-01-163 is an allosteric EGFR degrader that selectively inhibit the proliferation of L858R/T790M (L/T) mutant Ba/F3 cells while leaving wildtype EGFR Ba/F3 cells unaffected;DDC-01-163 exhibited an acceptable biochemical potency with an IC50 value of 45 nM against EGFR L858R/T790M.DDC-01-163 is also effective against osimertinib-resistant cells with L/T/C797S and L/T/L718Q EGFR mutations.The anti-proliferative activity of DDC-01-163 against L858R/T790M EGFR-Ba/F3 cells is enhanced when combined with an ATP-site EGFR inhibitor, Osimertinib. |
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| References | 1. Jaebong Jang, et al. Angew Chem Int Ed Engl. 2020 Aug 17;59(34):14481-14489. |
| Molecular Formula | C49H51N9O9S |
|---|---|
| Molecular Weight | 942.061 |