DDC-01-163

Modify Date: 2025-08-25 13:02:33

DDC-01-163 Structure
DDC-01-163 structure
 Common Name DDC-01-163
CAS Number 2140806-84-2 Molecular Weight 942.061
Density N/A Boiling Point N/A
Molecular Formula C49H51N9O9S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of DDC-01-163


DDC-01-163 is an allosteric EGFR degrader that selectively inhibit the proliferation of L858R/T790M (L/T) mutant Ba/F3 cells while leaving wildtype EGFR Ba/F3 cells unaffected;DDC-01-163 exhibited an acceptable biochemical potency with an IC50 value of 45 nM against EGFR L858R/T790M.DDC-01-163 is also effective against osimertinib-resistant cells with L/T/C797S and L/T/L718Q EGFR mutations.The anti-proliferative activity of DDC-01-163 against L858R/T790M EGFR-Ba/F3 cells is enhanced when combined with an ATP-site EGFR inhibitor, Osimertinib.

 Names

Name DDC-01-163

 DDC-01-163 Biological Activity

Description DDC-01-163 is an allosteric EGFR degrader that selectively inhibit the proliferation of L858R/T790M (L/T) mutant Ba/F3 cells while leaving wildtype EGFR Ba/F3 cells unaffected;DDC-01-163 exhibited an acceptable biochemical potency with an IC50 value of 45 nM against EGFR L858R/T790M.DDC-01-163 is also effective against osimertinib-resistant cells with L/T/C797S and L/T/L718Q EGFR mutations.The anti-proliferative activity of DDC-01-163 against L858R/T790M EGFR-Ba/F3 cells is enhanced when combined with an ATP-site EGFR inhibitor, Osimertinib.
References 1. Jaebong Jang, et al. Angew Chem Int Ed Engl. 2020 Aug 17;59(34):14481-14489.

 Chemical & Physical Properties

Molecular Formula C49H51N9O9S
Molecular Weight 942.061
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Chemsrc provides DDC-01-163(CAS#:2140806-84-2) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of DDC-01-163 are included as well.>> amp version: DDC-01-163

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