R-IMPP

Modify Date: 2024-01-28 17:10:37

R-IMPP Structure
R-IMPP structure
Common Name R-IMPP
CAS Number 2133832-83-2 Molecular Weight 389.49
Density N/A Boiling Point N/A
Molecular Formula C24H27N3O2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of R-IMPP


R-IMPP is an inhibitor of PCSK9 secretion.

 Names

Name R-IMPP

 R-IMPP Biological Activity

Description R-IMPP is an inhibitor of PCSK9 secretion.
Related Catalog
In Vitro R-IMPP stimulates uptake of LDL-C in hepatoma cells by increasing LDL-R levels, without altering levels of secreted transferrin. R-IMPP does not decrease PCSK9 transcription or increase PCSK9 degradation, but causes transcript-dependent inhibition of PCSK9 translation. R-IMPP is able to selectively bind to human, but not E. coli, ribosomes[1].
References

[1]. Petersen DN, et al. A Small-Molecule Anti-secretagogue of PCSK9 Targets the 80S Ribosome to Inhibit PCSK9 Protein Translation. Cell Chem Biol. 2016 Nov 17;23(11):1362-1371

 Chemical & Physical Properties

Molecular Formula C24H27N3O2
Molecular Weight 389.49
Storage condition -20℃
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